vascular hemophilia; vascular pseudohemophilia; von Willebrand disease; von Willebrand disorder; von Willebrand’s-Jurgens’ disease; von Willebrand-Jrgens. The activity of vWF in a patient with von Willebrand disease. Aktywość vWF u pacjenta z chorobą Willebranda. Fig. 4. The activity of vWF in a. Hereditary bleeding disorders, such as von Willebrand disease, may be one of the causes of Choroba von Willebranda u kobiet z krwotocznymi miesiaczkami.

Author: Groramar Munris
Country: Germany
Language: English (Spanish)
Genre: Travel
Published (Last): 15 April 2012
Pages: 461
PDF File Size: 5.27 Mb
ePub File Size: 5.72 Mb
ISBN: 789-6-43666-820-5
Downloads: 19932
Price: Free* [*Free Regsitration Required]
Uploader: Mazukus

Von Willebrand disease vWD is the most common hereditary blood-clotting disorder in humans. The International Society on Thrombosis and Haemostasis ‘s classification depends on the definition of qualitative and quantitative defects.

Symptoms Most often, vWD is diagnosed as part of a presurgical or routine blood screen, especially for at-risk breeds. Started inthis collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters.

Since the vWF protects coagulation factor VIII from proteolytic degradation, total absence of vWF leads to extremely low factor VIII level, equivalent to that seen in severe hemophilia A with its clinical manifestations of life-threatening external and internal hemorrhages.

Therefore, those pigs are valuable models for clinical and pharmacological research. This is due to the large vWF multimers remaining bound to the patient’s platelets. Those individuals with blood group O have a lower mean level than individuals with other blood groups.

In angiodysplasiaa form of telangiectasia of the colonshear stress is much higher than in average capillariesand the risk of bleeding is increased concomitantly.


Other coagulation factor assays may be performed depending on the results of a coagulation screen. The Man Behind the Syndrome. Content is updated monthly with systematic literature reviews and conferences.

Retrieved 3 December For the normal function of the coagulation factor, see von Willebrand factor. It’s important to carefully watch your dog for symptoms and to prevent unnecessary bumps and bruises to help keep her safe.

Von Willebrandova choroba – WikiSkripta

Search Bing for all related images. Disease or Syndrome T Related Bing Images Extra: Related Topics in Coagulopathy. Please review the contents of the section and add the appropriate references if you can.

Diseases of clotting D50—69,74— Views Read Edit View history.

Please help improve this article by adding citations to reliable sources. It has 52 exons spanning kbp.

Administration of ethinylestradiol diminishes the secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary, leading to stabilization of the endometrial surface of the uterus.

Signs and symptoms include bruises, nose bleeding, gum bleeding following a dental procedure, heavy menstrual bleeding, and gastrointestinal bleeding.

Von Willebrand disease: the most common hereditary haemorrhagic disorder

The three forms of vWD are: Most cases of type 1 vWD are never diagnosed due to the asymptomatic or mild presentation of type I and most people usually end up leading a normal life free of complications, willebranfa many being unaware that they have the disorder. In these strains, the vWF gene has been knocked out. The vWF is qualitatively normal and genetic testing of the von Willebrand gene and vWF protein reveals no mutational alteration.

In this case, the function of vWF is not inhibited, but the vWF-antibody complex is rapidly cleared from the circulation.


If your dog has vWD, make sure you tell your veterinarian, especially if your dog is scheduled for a surgical or dental procedure. Severe internal willebrands and bleeding into joints are uncommon in all willebrqnda the most severe type, vWD type 3. Platelet-type vWD also known as pseudo-vWD is an autosomal dominant genetic defect of the platelets. Most often, vWD is diagnosed as part of a presurgical or routine blood screen, especially for at-risk breeds. The various types of vWD present with varying degrees of bleeding tendencyusually in the form of easy bruising wllebranda, nosebleedsand bleeding gums.

It affects both male and female dogs equally, and while any dog can have vWD, there are several breeds that are at greater risk:. Trouble may, however, arise in some patients in the form of bleeding following surgery including dental proceduresnoticeable easy bruising, or menorrhagia heavy menstrual periods.

Von Willebrand’s Disease in Dogs

In more severe cases of type 1 vWD, genetic changes are common within the vWF gene and are highly penetrant. The testing for vWD can be influenced by laboratory procedures. When a dog has too few platelets, wounds and injuries can be really dangerous because he or she might not stop bleeding and lose a lot of excess blood.