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It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden. To calculate molar mass of a chemical compound, please enter its chemical formula and click datashest. Media is changed at day 4, viable cell numbers are restored to the original concentration and compounds are re-supplied.
Single Ic ≤ 500 MA NPN Silicon Digital Transistor
For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 7 days, then harvested, washed and incubated with Pacific Blue rat anti-mouse CD11b antibody before being analyzed by flow cytometry. Menin-MLL interaction  Cell-free assay. We do not sell to patients. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for ncr assays and animal experiments.
Not for human use.
BCR E Infineon Technologies, BCR E Datasheet
The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect achieved after days of treatment. Treatment with sub-micromolar concentrations of MI also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias .
Calculate the dilution required to prepare a stock solution. Answers to questions you may have can be found in the inhibitor handling instructions. The Selleck molarity calculator is based on the following equation:.
Histone Methyltransferase Signaling Pathway Map. These effects are accompanied by reduced c-kit CD expression, a marker associated with leukemia stem cells LSCs. The Selleck dilution calculator is based on the following equation: In vivo MI has very favorable datasheeet properties, including metabolic stability and pharmacokinetic profile in mice.
This is normal and is due to slight batch-to-batch variations.
BCR Datasheet, Equivalent, Cross Reference Search. Transistor Catalog
Molecular mass molecular weight is the mass of one molecule of ncr substance and is expressed in the unified atomic mass units u. Serial Dilutions Concertration start: Products are for research use only.
Tech Support Answers to questions you may have can be found in the inhibitor handling instructions.
MI could substantially improve survival of MLL leukemic mice and does not impair normal hematopoiesis in vivo . Calculate the mass, volume or concentration required for a solution. This equation is commonly abbreviated as: The Selleck molarity calculator is based on the following equation: Prolonged treatment 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues.
Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines GI50 at nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations.
Choose Selective Histone Methyltransferase Inhibitors. The Selleck dilution calculator is based on the following equation:.
References  Borkin D, et al. Molecular Weight Calculator Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental composition: For viability assays, leukemia cells are plated at relevant concentrations and treated with compounds or 0. Chemical formula is case sensitive. MI has datadheet favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice.
Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution. MI is also very effective in inducing differentiation of MLL leukemia cells and substantially bfr expression of CD11b, a myeloid differentiation marker.